Clouseau was set up by Bob Savenberg, who named the band after Inspector Clouseau, a character he enjoyed imitating and after whom he had named his radio station.

Initially, Clouseau only performed local acts, which were often successful. Singer Koen Wauters soon left the group to sing for another local band, but in 1987 he was persuaded to return.

The same year they were discovered at the Marktrock festival in Leuven, Belgium. Their first single Brandweer (Firemen, also a pun which can be interpreted as "Burning again") sold 427 copies. Their television debut followed in November of that year.

In 1989 Clouseau participated in the Belgian tryouts for the Eurovision Song Contest with the song Anne. Clouseau came in second, but Anne became an enormous hit in Belgium and a (minor) hit in the Netherlands. The popularity of Clouseau in Belgium skyrocketed, and that year Clouseau produced its first album, Hoezo? (Whaddayamean?).

In 1990 Daar gaat ze topped the singles charts in both Belgium and the Netherlands; several more hits. On September 30, Tjen Berghmans left the group after a dispute.

In October 1990 Clouseau released their second album, Of zo... (Or so...). In March 1991, Karel Theys departed, leaving Clouseau as a three-piece. A month later Clouseau came in 16th in the Eurovision Song Contest with Geef het op, but their participation resulted in a European breakthrough.

After Koen Wauters served four weeks in the army Clouseau released their first English language album; Close Encounters was a huge success in Germany. The Dutch fans were less keen on the idea of Koen Wauters singing in another language and rather bought the live-album that was released during this period.

In 1992 Clouseau released a Dutch-language album, Doorgaan (Keep on; as in "Keep on till you turn legless", a phrase from extracted single Vanavond Ga Ik Uit). At the same time, they supported Swedish group Roxette on their European tour performing the Close Encounters-material.

The second English-language album, 1993's In every small town was recorded in Los Angeles. However, the album failed critically, receiving little attention outside the Benelux countries. Since then, Clouseau has refrained from producing English-language music.

In 1995 they releases the Oker album which featured the single Passie. In 1996, founder Bob Savenberg left the group. At the time he hosted the television format of the Ultratop 50 and had the luxury of interviewing Roxette. Bob Savenberg now works with upcoming artists as a manager.

In September they released the Adrenaline-album which was promoted with a large tour.

On December 22, 1998 singer Koen Wauters married the Dutch television journalist and one-time MTV-presenter Carolyn Lilipaly (they divorced in 2002). 1999 saw the release of the In Stereo. Clouseau were heading for a new direction. A live album was released in 2000, and Clouseau were touring Belgium and the Netherlands where they played their last shows to date.

In 2001, Clouseau released the disco oriented CD En Dans (And Dance); the artwork was designed by Marcel Vanthilt and the title track became a huge hit. Whilst the fans were waiting for new material, the two remaining bandmembers presented the 2003 and 2004 editions of Idool (the Belgian version of Idols) on VTM. In October they released the Vanbinnen (Inside) album.

Since 2002 Clouseau are playing multiple Christmas shows at the Antwerp Sports Palace. These concerts are a huge success with tickets selling out well in advance and each year's series surpassing the previous. In 2005, 13 shows attracted over 200,000 visitors. (13 x 17,500) Due to Koen's Dakar-participation they couldn't add any further dates.

In 2006 Clouseau performed in Antwerp at the 0110 concerts for tolerance, organised by Tom Barman, singer/guitarist with dEUS. At that moment seven shows were added for that year's Christmas stint (Clouseau Speciale Editie).

The band released their latest CD Vonken & Vuur ("Sparks & Flames") in March 2007 with De Tegenpartij (The Opposition Party) being the first single. The Dutch release followed a month later.

Theur 20th anniversary was celebrated with a tribute-album; Braveau Clouseau.

Late 2007 Koen Wauters expressed his disappointment with Clouseau's dwindling popularity in the Netherlands over the last ten years; the record company chose not to promote albums assuming that they'd sell themselves. Although Koen regrets this move he has no intention of regaining lost ground, and certainly not by appearing on radio-shows where "egomaniacs" are reigning supreme. He also reckons that Clouseau have become redundant now that the Dutch are looking towards homegrown acts again, with only Marco Borsato matching the band's recent glories.